A few of our customers have experienced a problem where the U3 chip on the HP488 board (and possibly also the regulator - U2) are getting very hot and when this happens the chip on the board cannot be reprogrammed.
If you are experiencing this issue, please contact us via the webpage below explaining that you have the "U3/regulator getting too hot problem" and we will provide you with a fix:
http://www.matrixmultimedia.com/contact2.php
